SwitchGear Genomics © SwitchGear Genomics

DNA METHYLATION ASSAY - Download the PDF

Identify global patterns of DNA methylation using SwitchGear’s unique methylation assay
  • Use SwitchGear's methylation service to measure global patterns of methylation in the human or mouse genomes from any cell or tissue sample
  • Integrate DNA methylation information with other genomic data generated by SwitchGear's suite of tools to provide a more complete view of a regulatory network
  • Genome-wide DNA methylation patterns serve as valuable epigenetic signatures to profile different tumor types or tissue samples
  • Use in conjunction with the SwitchGear Functional Promoter Macroarray to measure the functional effects of DNA methylation on a particular promoter
DNA Methylation

Details of the SwitchGear methylation assay platform:
  • Methylation assay conducted on a custom-designed ~400,000 feature oligo array
  • Measures methylation status at ~50,000 unique regions ranging in size from 300 to 2,000 bp in the human genome
  • Covers ~20,000 additional CpG-rich regions that are not annotated as “CpG islands”
  • Includes 1,000 negative control regions that lack CpGs
Requirments for the methylation assay:
  • > 200 ng high-molecular weight genomic DNA (average size > 4 kb)
SwitchGear’s methylation technology is currently available as a service. By providing genomic DNA samples, you can quickly measure the methylation patterns across hundreds of samples without investing in additional infrastructure and personnel.

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