Measure the activity of more than 3,000 promoters of cancer-related genes in a high-throughput, efficient, and economic way
The SwitchGear Oncology Promoter Set consists of ~3,000 unique 1kb human promoter fragments representing ~2,000 genes. The promoters are cloned into a custom vector containing an optimized luciferase reporter gene and are ready for transfection into living cells. The set is delivered in 96 or 384-well format with each well containing a unique promoter fragment.
The oncology set was designed to provide the most comprehensive list of transcriptional promoters related to cancer biology and were chosen from the SwitchGear genome-wide library of human promoters. The list was developed from primary literature, gene annotation, and gene ontology terms.
The oncology family is also available in smaller subsets designed for specific areas of interest:
- Apoptosis ~1,000 promoters
- Cell cycle ~1,000 promoters
- Hypoxia ~400 promoters
- DNA damage ~500 promoters
- p53 ~100 promoters